There is no magic powder, 231 is close.
I will be testing it out this week on .45, but i've heard and seen nothing but good things from powder.
W231 / HP38 / WSF / power pistol
231 is just okay, there is a lot of load data out there. There are several cleaner, and softer shooting powders out there.
Lee says to wash your powder dipper in a solution of dish soap and water, then let it air dry to take care of static.
Blasphemy!!!! Blasphemy, I tell ya!!!!!!
I've had really good luck with Titegroup. Meters great, shoots great, and is a very compact powder that really goes a long way.
Only downside is it is a little dirty and smoky with lead bullets.