BenL
John Galt Speaking.
You could certainly try them in your rifle to see what they'll do. As long as some factory throats are, you may find that you can drive them fast enough to see any help.
If you're trying to get a working load together in time to load some for the 25th, you may want to stick with the very well proven combo of Varget & 175s just to make it easy on yourself.
I'll definitely hang on to them to experiment with later, but I'm going to start with the 175's and shoot those for while.