Dad's mold for the Keith bullet he loaded most in 45 Colt was the 250 gr. I'm not sure what the difference might have been between the 250 and 255 gr molds, but the bullet that's listed over and over again for 45 Colt in his ledgers is the 250 gr with usually 9.0 or 10.0 gr Unique, with the occasional 9.5 gr or even 10.3 gr.Unique and a 255 grain Keith have long been like ham and eggs with 45 Colt for a Colt SSA or Uberti clone revolver. Then probably around the time your Dad got his Ruger, that's when you start seeing the Magnum powders. Would make all kinds of sense. With the Ruger, he could range from mild to wild, and anywhere in between as the revolver is much stronger. Great round!
There doesn't seem to be any real rhyme or reason for the deviation from one to the other, although past a certain point it's almost always 10.0 gr rather than the 9.0, and I suspect it's when he retired the 1st Gen Colt SAA because it was becoming valuable, and when he got the stronger Ruger.
Sorry - this has strayed a bit from the original topic of the thread - mag primers with Titegroup - but I do find it interesting to go back through his ledgers.