HordesOfKailas
Still learning
I think in general, if you hit your target (not a graze or a glance, a good central shot) you run a minimal chance of overpenetration.
Not familiar with Clerke revolvers.
If you want information on caliber effectiveness, I found the following article pretty enlightening.
https://www.buckeyefirearms.org/alternate-look-handgun-stopping-power
I was surprised at how effective some of the smaller calibers could be given what people have been saying about the larger ones.