Hey Sirex!Welcome to MDS. I hope you enjoy it here.
I, would get a 9mm handgun for home defense and the 45 1911 second. I would get a modular 9mm that you can swap a .22 slide on for cheap practice and plinking, like a Glock, Sig, or CZ. Or get an airsoft version of whatever real gun you get to familiarize yourself with and practice around the house. I got a CZ75 in 9mm, a .22 Kadet kit, and an airsoft version for playing with in the basement. I also have a 45 for fun or potential home defense. Just my opinion based on cost/capacity.
Thank you for the thoughtful reply! I like the idea of looking into airsoft/bb models to use for familiarity in the home and the advice on a modular firearm. I'll certainly keep this in mind when making the final decision. I'll also look into a CZ75 so thank you for the recommendation!
Wishing you a great start to your week.