and one have a good load for deer and coyotes? I primarily use it for foxes and coyotes but haven't started reloading it yet.
In the 22-250 (I have sworn off 22-250s in favor of 22-250AIs as I HATE trimming brass and full length sizing), I used to run 65gr Sierra GameKings pushed by an over the limit charge of IMR4064 when specifically going after critters larger than groundhogs. If they are tough enough for red kangaroos and the like, deer are no problem. An excellent projectile is the Nosler 64gr BSB. I do not use it personally but a good friend (also running a 22-250AI) uses it as an all-around deer, yote, or whatever projectile inside 500yd. It's BC isn't stellar and you must consider background issues as it is designed to hold together even at high speeds. It WILL exit deer when driven to the speeds our guns operate at so be warned. The Nosler 60 partition, though I do not use it in my own guns, has proven much more accurate than I expected when loaded for others. I'd start with a middle charge of Varget or IM4064 and work up. Keep the bullet at least .020 off the lands.
On groundhog duty, with only varmint ammo in the bag, I've killed more than a small number of deer using a 40gr Nosler BT to the head or upper neck for damage permit deer. These shots ARE NOT body shots. Varmint bullets are inhumane when used anywhere else. The wounding will be horrific but the animal will expire very slowly if at all. The main reason for these shots is that no edible tissue is damaged and the whole animal may be used or donated.