Yesterday I had 3 or 4 rounds out of 50 that failed to fire. These were.45 cal reloads with 230gn plated bullets, 4.5gn bullseye powder, and CCI large pistol primers. All had nice dimples on the primers so no firing pin issues. Unfortunately I didn't bring any of them home to disassemble, but I find it hard to believe that I forgot to add powder to the cartridge, yet that is the only thing I can imagine happened. Defective primers are pretty rare aren't they?