Not in my experience , I shot a rabid raccoon with 3 45 caliber 230 grain bullets in the top of the skull before it died . it was getting to close for comfort I wished the Mauser was loaded
Years ago there was a rabid one out actually behind the police station where I was working. Officer who got stuck with the duty used an 870 loaded with 00 buck to make it as quick and merciful as possible. Thing stil went down hissing and fighting after it was shot.